Depo-Provera vs Provera: What’s the real difference?

If you’re looking at an injectable birth control, you’ll probably see two names pop up: Depo-Provera and Provera. Both are progesterone‑based shots, but they aren’t identical. Below we break down how each works, how often you need to get the shot, what side effects to expect, and which one might fit your lifestyle and budget.

How the injections work

Both shots contain medroxyprogesterone acetate, a synthetic form of the hormone progesterone. The hormone stops ovulation, thickens cervical mucus and makes the lining of the uterus less friendly for a fertilized egg. In simple terms, they create a chemical environment where pregnancy can’t happen.

Depo-Provera is usually given as a 150 mg injection every 12 weeks (about three months). The dose is higher, which is why the interval is longer. Provera, on the other hand, is a 75 mg shot that you need every 8 weeks (roughly two months). The lower dose means the body clears it faster, so you have to go back sooner.

Both are administered in the upper arm or buttock. You can get them at a doctor’s office, a family planning clinic, or sometimes at a pharmacy with a prescription. If you’re comfortable giving yourself the shot, a nurse can teach you how, but most people let a professional do it.

Key differences to consider

Frequency. Depo‑Provera’s three‑month schedule is convenient if you don’t want to think about appointments often. Provera’s eight‑week schedule means you’ll need more visits, which can be a hassle but also gives you more chances to check in with your provider.

Side‑effect profile. Both can cause similar things: irregular bleeding, weight gain, headache, and mood changes. Because Depo‑Provera delivers a larger dose, some users report a stronger impact on weight or menstrual changes. Provera’s lower dose may feel milder, but the evidence isn’t crystal clear – personal response varies a lot.

Cost. In many places, Depo‑Provera is cheaper per year because you need fewer shots. However, insurance coverage can flip the script. Check your plan: some insurers list Provera as the covered option, making it the more affordable choice for you.

Return of fertility. After stopping Depo‑Provera, it can take 10‑12 months for periods to come back to normal. Provera’s shorter dosing cycle might let your cycle reset a bit faster, though the difference isn’t huge.

Convenience. If you travel a lot or have a busy schedule, the three‑month shot can save you time. If you prefer more frequent check‑ins with your doctor to discuss any side effects, the eight‑week schedule can be a plus.

Bottom line: Both injections are effective (about 99 % with perfect use). Your decision should hinge on how often you want to visit a clinic, how your body reacts to hormone levels, and what your insurance or budget allows.

Before you choose, talk with a healthcare provider about your medical history, any clotting disorders, and how you feel about menstrual changes. A quick chat can help you land on the shot that matches your lifestyle the best.

Remember, no birth control method is one‑size‑fits‑all. If you start with Depo‑Provera and it doesn’t feel right, you can switch to Provera – or explore pills, IUDs, or implants. The goal is to find a safe, affordable, and hassle‑free option that lets you focus on the things that matter most.