Tag: NTI drugs

How to Understand Narrow Therapeutic Index Drugs and Generics

Narrow therapeutic index drugs require extreme precision in dosing. Understanding how generics interact with these medications is critical for safety. Learn which drugs are NTI, why substitutions can be risky, and how to protect yourself.

Prescriber Attitudes on NTI Drug Substitution: Risks, Regulations, and Current Practices

Prescribers have mixed views on substituting generic versions of Narrow Therapeutic Index drugs. FDA guidelines and state laws influence decisions, with some states requiring patient consent. Real-world data shows higher brand usage for critical NTI drugs like warfarin and tacrolimus. Communication between doctors and pharmacists is key to managing substitution risks. Ongoing research aims to improve safety and trust in generic NTI options.

Should You Stay on Brand NTI Drugs When Generic Substitution Is Allowed?

Should you stick with brand-name NTI drugs even when generics are allowed? For drugs like levothyroxine and warfarin, small changes in dosage can cause serious harm. Learn when to stay on brand and when a generic is safe.

Theophylline Levels: Why Narrow Therapeutic Index Monitoring Is Critical for Patient Safety

Theophylline has a narrow therapeutic index, meaning even small changes in dosage or metabolism can lead to dangerous toxicity. Regular blood monitoring is essential to keep levels between 10-20 mg/L and avoid life-threatening side effects.